AIDSVAX flop leaves vaccine field unscathed

Analysis of V2 Antibody Responses Induced in Vaccinees in the ALVAC/AIDSVAX HIV-1 Vaccine Efficacy Trial

The RV144 clinical trial of a prime/boost immunizing regimen using recombinant canary pox (ALVAC-HIV) and two gp120 proteins (AIDSVAX B and E) was previously shown to have a 31.2% efficacy rate. Plasma specimens from vaccine and placebo recipients were used in an extensive set of assays to identify correlates of HIV-1 infection risk. Of six primary variables that were studied, only one displaye...

Antigenicity and immunogenicity of RV144 vaccine AIDSVAX clade E envelope immunogen is enhanced by a gp120 N-terminal deletion.

An immune correlates analysis of the RV144 HIV-1 vaccine trial revealed that antibody responses to the gp120 V1/V2 region correlated inversely with infection risk. The RV144 protein immunogens (A244-rp120 and MN-rgp120) were modified by an N-terminal 11-amino-acid deletion (Δ11) and addition of a herpes simplex virus (HSV) gD protein-derived tag (gD). We investigated the effects of these modifi...

The 1954 Salk poliomyelitis vaccine field trial.

Flip-Flop Nets

The so-called synthesis problem for nets which consists in deciding whether a given automaton is isomorphic to the case graph of a net and then constructing the net has been solved for various type of nets ranging from elementary nets to Petri nets. Though P/T nets admits polynomial time synthesis algorithms, the synthesis problem for elementary nets is known to be NP-complete. Applying the pri...

Ferroelectric polarization flop in a frustrated magnet MnWO4 induced by a magnetic field.

The relationship between magnetic order and ferroelectric properties has been investigated for MnWO4 with a long-wavelength magnetic structure. Spontaneous electric polarization is observed in an elliptical spiral spin phase. The magnetic-field dependence of electric polarization indicates that the noncollinear spin configuration plays a key role for the appearance of the ferroelectric phase. A...